This research first proposed the method to estimate the Irregularly $paced Intraday Value atRisk (ISIVaR) and solve the problem result from the irregularly spaced and asynchronous multivariatetick-by-tick data. Firstly, this research makes use of the auto correlation duration model to fit theprice durations of each single asset in the portfolio. Then, based on the duration, the assets’ intradayvolatility and ISIVaR, is estimated. Next, by Fresh Time method, this research synchronizes the priceevents sequences of the portfolio. Then, the Copula theory is used to model the irregularly spacedintraday volatility in order to capture the cross-sectional correlation information between the assets inthe portfolio. Fimally, based on the cross-section correlation, the ISIVaR of the portfolio is estimated bvMonte Carlo simulation method, At the end of this research, an empirical study is presented to validatethe feasibility of the proposed method.